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Article

The effect of folate deficiency on the hprt mutational spectrum in Chinese hamster ovary cells treated with monofunctional alkylating agents.

Mutation research - 30 Jun 1999

Branda R F, Lafayette A R, O'Neill J P, Nicklas J A

Abstract excerpt

Folic acid deficiency acts synergistically with alkylating agents to increase DNA strand breaks and mutant frequency at the hprt locus in Chinese hamster ovary (CHO) cells. To elucidate the mechanism of this synergy, molecular analyses of hprt mutants were performed. Recently, our laboratory showed that folate deficiency increased the percentage of clones with intragenic deletions after exposure to ethyl...

Read the complete abstract on PubMed

Topics

Alkylating Agents
Animals
Base Pairing
CHO Cells
Cricetinae
DNA Mutational Analysis
DNA Primers

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

DNA Repair

Ethyl Methanesulfonate

Ethylnitrosourea

Folic Acid Deficiency

Guanine

Hypoxanthine Phosphoribosyltransferase

Mutagens

Mutation

Polymerase Chain Reaction

Thioguanine

Source

Identifiers

PMID: 10393262
DOI: 10.1016/s0027-5107(99)00095-0

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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