DNA alkylations and mutation after exposure to ethyl methanesulphonate in mammalian cell lines routinely used in mutagenicity testing.

Article

DNA alkylations and mutation after exposure to ethyl methanesulphonate in mammalian cell lines routinely used in mutagenicity testing.

Mutagenesis - 1 Jan 1990

Waters R, Henderson L, Wilcox P, O'Donovan M R

Abstract excerpt

DNA ethylations were measured in four mammalian cell lines, Chinese hamster ovary CHO, mouse lymphoma L5178Y t k+/-, human lymphoblastoid TK6 and Chinese hamster V79, following exposure to [3H]ethyl methanesulphonate. Concurrent estimates of cytotoxicity and gene mutation were also carried out. T...

Topics

Adenine
Alkylation
Animals
Cell Line
Chromatography, High Pressure Liquid
DNA
DNA Damage
Ethyl Methanesulfonate
Guanine
Humans
Mutagenicity Tests
Mutagens
Mutation
Tritium

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