The mutagenic response at the ouabain resistance locus in T cells of mice exposed to N-ethyl-N-nitrosourea parallels the response at the Hprt locus and correlates with mutation target size.

doi:10.1093/carcin/18.11.2233

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Article

The mutagenic response at the ouabain resistance locus in T cells of mice exposed to N-ethyl-N-nitrosourea parallels the response at the Hprt locus and correlates with mutation target size.

Carcinogenesis - 1 Nov 1997

Dass S B, Heflich R H, Casciano D A

Abstract excerpt

The lymphocyte Hprt gene has been used extensively as a reporter locus to monitor the mutational effects of the exposure of animals to genotoxicants. Implicit in this view of the function of a reporter gene is the assumption that its mutagenic response is representative of that of other genes in...

Topics

Animals
Chromosome Mapping
Ethylnitrosourea
Female
Hypoxanthine Phosphoribosyltransferase
Mice
Mice, Inbred C57BL
Mutagens
Mutation
Ouabain
T-Lymphocytes
Thioguanine

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