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Article

Unusual properties of a replication-defective mutant SV40 large T antigen.

Virology - 1 Feb 1993

Lorimer H E, Reynisdóttir I, Ness S, Prives C

Abstract excerpt

The C11A mutant of SV40 large T antigen is unable to support the replication of viral origin containing DNA (ori-DNA) in vivo or in vitro. The mutation within C11A at residue 522 (pro-->ser) is located within the presumptive ATPase region of T antigen. While C11A T antigen was previously reported to be defective in ATPase and DNA helicase activities, it was shown to be capable of binding specifically to DNA...

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Identifiers

PMID: 8380658
DOI: 10.1006/viro.1993.1055

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