Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Two conditional tsA mutant simian virus 40 T antigens display marked differences in thermal inactivation.

Journal of virology - 1 Nov 1992

Reynisdóttir I, Prives C

Abstract excerpt

We have characterized the simian virus 40 (SV40) origin-containing DNA (ori-DNA) replication functions of two SV40 conditional mutant T antigens: tsA438 A-V (tsA58) and tsA357 R-K (tsA30). Both tsA mutant T antigens, immunopurified from recombinant baculovirus-infected insect cells, mediated replication of SV40 ori-DNA in vitro to similar extents as did wild-type T antigen in reactions at 33 degrees C. However,...

Topics

Antigens, Viral, Tumor
Baculoviridae
Cell-Free System
Chromosome Mapping
DNA Helicases
DNA Replication
DNA Topoisomerases, Type I
DNA, Viral
Hot Temperature
Mutation
Protein Conformation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Protein Denaturation

Recombinant Proteins

Simian virus 40

Source

Open in PubMed Open full text

Identifiers

PMID: 1328678
DOI: 10.1128/JVI.66.11.6517-6526.1992
PMCID: PMC240145

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1328678-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Two conditional tsA mutant simian virus 40 T antigens display marked differences in thermal inactivation.PMID 1328678Read ↗

Thermally inactivated simian virus 40 tsA58 mutant T antigen cannot initiate viral DNA replication in vitro.Semantic proximity Read ↗

Functional characterization of temperature-sensitive mutants of simian virus 40 large T antigen.Semantic proximity Read ↗

The kinetics of simian virus 40-induced progression of quiescent cells into S phase depend on four independent functions of large T antigenSemantic proximity Read ↗

Unusual properties of a replication-defective mutant SV40 large T antigen.Semantic proximity Read ↗

Simian virus 40 large-T antigen expresses a biological activity complementary to the p300-associated transforming function of the adenovirus E1A gene products.Semantic proximity Read ↗

Four major sequence elements of simian virus 40 large T antigen coordinate its specific and nonspecific DNA binding.Semantic proximity Read ↗

Simian virus 40 large T-antigen function is required for induction of tetraploid DNA content during lytic infection.Semantic proximity Read ↗

Converting the JCV T antigen Rb binding domain to that of SV40 does not alter JCV's limited transforming activity but does eliminate viral viability.Semantic proximity Read ↗

Phenotype-specific phosphorylation of simian virus 40 tsA mutant large T antigens in tsA N-type and A-type transformants.Semantic proximity Read ↗

A TEF-1-independent mechanism for activation of the simian virus 40 (SV40) late promoter by mutant SV40 large T antigens.Semantic proximity Read ↗

The cellular chromatin is an important target for SV40 large T antigen in maintaining the transformed phenotype.Semantic proximity Read ↗

Interaction of simian virus 40 large T-antigen with cellular DNA polymerase alpha: studies with various T-antigen mutants of SV40.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.