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Article

Two conditional tsA mutant simian virus 40 T antigens display marked differences in thermal inactivation.

Journal of virology - 1 Nov 1992

Reynisdóttir I, Prives C

Abstract excerpt

We have characterized the simian virus 40 (SV40) origin-containing DNA (ori-DNA) replication functions of two SV40 conditional mutant T antigens: tsA438 A-V (tsA58) and tsA357 R-K (tsA30). Both tsA mutant T antigens, immunopurified from recombinant baculovirus-infected insect cells, mediated replication of SV40 ori-DNA in vitro to similar extents as did wild-type T antigen in reactions at 33 degrees C. However,...

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Identifiers

PMID: 1328678
DOI: 10.1128/JVI.66.11.6517-6526.1992
PMCID: PMC240145

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