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Article

Identification of simian virus 40 T-antigen residues important for specific and nonspecific binding to DNA and for helicase activity.

Journal of virology - 1 Oct 1990

Simmons D T, Wun-Kim K, Young W

Abstract excerpt

We have previously identified three regions (called elements) in the DNA-binding domain of simian virus 40 large tumor (T) antigen which are critical for binding of the protein to the recognition pentanucleotides GAGGC at the viral replication origin. These are elements A (residues 147 to 159), B1 (185 to 187), and B2 (203 to 207). In this study, we generated mutants of simian virus 40 in order to make...

Topics

Amino Acid Sequence
Animals
Antigens, Polyomavirus Transforming
Binding Sites
Cell Line
DNA
DNA Helicases
DNA, Viral
Drug Combinations
Molecular Sequence Data
Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Protein Binding

Sequence Homology, Nucleic Acid

Simian virus 40

Virus Replication

Source

Open in PubMed Open full text

Identifiers

PMID: 2168972
DOI: 10.1128/JVI.64.10.4858-4865.1990
PMCID: PMC247975

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2168972-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Identification of simian virus 40 T-antigen residues important for specific and nonspecific binding to DNA and for helicase activity.PMID 2168972Read ↗

Four major sequence elements of simian virus 40 large T antigen coordinate its specific and nonspecific DNA binding.Semantic proximity Read ↗

The DNA-binding domain of simian virus 40 tumor antigen has multiple functions.Semantic proximity Read ↗

Functional characterization of temperature-sensitive mutants of simian virus 40 large T antigen.Semantic proximity Read ↗

Three domains in the simian virus 40 core origin orchestrate the binding, melting, and DNA helicase activities of T antigen.Semantic proximity Read ↗

T Antigens of Simian Virus 40: Molecular Chaperones for Viral Replication and TumorigenesisSemantic proximity Read ↗

An N-terminal deletion mutant of simian virus 40 (SV40) large T antigen oligomerizes incorrectly on SV40 DNA but retains the ability to bind to DNA polymerase alpha and replicate SV40 DNA in vitro.Semantic proximity Read ↗

Model for T-antigen-dependent melting of the simian virus 40 core origin based on studies of the interaction of the beta-hairpin with DNA.Semantic proximity Read ↗

Simian virus 40 mutants with amino-acid substitutions near the amino terminus of large T antigen.Semantic proximity Read ↗

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The zinc finger region of simian virus 40 large T antigen is needed for hexamer assembly and origin melting.Semantic proximity Read ↗

Simian virus 40 T-antigen DNA helicase is a hexamer which forms a binary complex during bidirectional unwinding from the viral origin of DNA replicationSemantic proximity Read ↗

Database of mutations that alter the large tumor antigen in simian virus 40.Semantic proximity Read ↗

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