Article
Converting the JCV T antigen Rb binding domain to that of SV40 does not alter JCV's limited transforming activity but does eliminate viral viability.
Virology - 1 Mar 1994
Tavis J E, Trowbridge P W, Frisque R J
Abstract excerpt
Two sets of mutations were introduced into a region of the JC virus (JCV) large tumor (T) antigen involved in binding the retinoblastoma susceptibility gene product (Rb). The first set converted the JCV sequences to those found in the corresponding region of the simian virus 40 (SV40) T antigen....
Topics
- Amino Acid Sequence
- Animals
- Antigens, Polyomavirus Transforming
- Binding Sites
- Cell Line
- Cell Transformation, Viral
- Centrifugation, Density Gradient
- DNA Replication
- DNA, Viral
- JC Virus
- Molecular Sequence Data
- Mutation
- Protein Binding
- Rats
- Retinoblastoma Protein
- Simian virus 40
- Virus Replication