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Article

Four major sequence elements of simian virus 40 large T antigen coordinate its specific and nonspecific DNA binding.

Journal of virology - 1 May 1990

Simmons D T, Loeber G, Tegtmeyer P

Abstract excerpt

By mutational analysis, we have identified a motif critical to the proper recognition and binding of simian virus 40 large tumor antigen (T antigen) to virus DNA sequences at the origin of DNA replication. This motif is tripartite and consists of two elements (termed A1 and B2) that are necessary for sequence-specific binding of the origin and a central element (B1) which is required for nonspecific DNA-binding...

Topics

Adenoviruses, Human
Amino Acid Sequence
Animals
Antigens, Polyomavirus Transforming
Cell Line
DNA, Viral
DNA-Binding Proteins
Models, Biological
Molecular Sequence Data
Mutation
Plasmids

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Recombination, Genetic

Simian virus 40

Transfection

Virus Replication

Source

Open in PubMed Open full text

Identifiers

PMID: 2157865
DOI: 10.1128/JVI.64.5.1973-1983.1990
PMCID: PMC249351

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2157865-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Four major sequence elements of simian virus 40 large T antigen coordinate its specific and nonspecific DNA binding.PMID 2157865Read ↗

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