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Article

Exosome-mediated recognition and degradation of mRNAs lacking a termination codon.

Science (New York, N.Y.) - 22 Mar 2002

van Hoof Ambro, Frischmeyer Pamela A, Dietz Harry C, Parker Roy

Abstract excerpt

One role of messenger RNA (mRNA) degradation is to maintain the fidelity of gene expression by degrading aberrant transcripts. Recent results show that mRNAs without translation termination codons are unstable in eukaryotic cells. We used yeast mutants to demonstrate that these "nonstop" mRNAs are degraded by the exosome in a 3'-to-5' direction. The degradation of nonstop transcripts requires the...

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Identifiers

PMID: 11910110
DOI: 10.1126/science.1067272

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Exosome-mediated recognition and degradation of mRNAs lacking a termination codon.PMID 11910110Read ↗

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