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Article

The power of association studies to detect the contribution of candidate genetic loci to variation in complex traits.

Genome research - 1 Aug 1999

Long A D, Langley C H

Abstract excerpt

The statistical power of five association study test statistics (two haplotype-based tests, two marker-based tests, and the Transmission Disequilibrium Test-Q5) to detect single nucleotide polymorphism (SNP)/phenotype associations in a linkage-disequilibrium-based candidate gene scan employing a number of SNPs is examined. Power is estimated as a function of realistic parameters expected to affect the likelihood...

Topics

Computational Biology
Genetic Markers
Genetic Variation
Genotype
Humans
Linkage Disequilibrium
Nucleotides
Phenotype
Polymorphism, Genetic
Quantitative Trait, Heritable

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 10447507
PMCID: PMC310800

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