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Article

Assessing the statistical power to detect linkage in a sample of 51 bipolar affective disorder pedigrees.

Behavior genetics - 1 Mar 1996

Lim L C, Craddock N, Owen M, Sham P, Nöthen M M, Körner J, Rietschel M, Fimmer R, Propping P, McGuffin P, Murray R, Gill M

Abstract excerpt

We used computer simulation method to address the question of power in an initial collaborative sample of 51 bipolar affective disorder pedigrees. Simulations were performed for all possible combinations using (1) two levels of diagnostic stringency, (2) three transmission models, (3) locus heterogeneity, and (4) different assumed phenocopy rates. Some of the factors affect the power to detect linkage are (1) the...

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PMID: 8639147
DOI: 10.1007/BF02359889

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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