Article
Assessing the statistical power to detect linkage in a sample of 51 bipolar affective disorder pedigrees.
Behavior genetics - 1 Mar 1996
Lim L C, Craddock N, Owen M, Sham P, Nöthen M M, Körner J, Rietschel M, Fimmer R, Propping P, McGuffin P, Murray R, Gill M
Abstract excerpt
We used computer simulation method to address the question of power in an initial collaborative sample of 51 bipolar affective disorder pedigrees. Simulations were performed for all possible combinations using (1) two levels of diagnostic stringency, (2) three transmission models, (3) locus heter...
Topics
- Adolescent
- Adult
- Aged
- Bipolar Disorder
- Chromosome Mapping
- Computer Simulation
- Female
- Gene Frequency
- Genes, Dominant
- Genetic Carrier Screening
- Genetic Linkage
- Humans
- Male
- Middle Aged
- Models, Genetic
- Phenotype
- Risk