Article
Analytic strategies to detect linkage to a common disorder with genetically determined age of onset: diabetes mellitus in Pima Indians.
Genetic epidemiology - 1 Jan 1998
Hanson R L, Knowler W C
Abstract excerpt
Segregation analysis suggests that the high prevalence of non-insulin-dependent diabetes mellitus in Pima Indians may be partially due to a single locus with a major effect on age of onset. A simulation study was conducted to evaluate the power of various age-adjustment strategies in linkage anal...
Topics
- Adolescent
- Adult
- Age of Onset
- Arizona
- Child
- Chromosome Mapping
- Computer Simulation
- Diabetes Mellitus, Type 2
- Genes, Dominant
- Genes, Recessive
- Genetic Linkage
- Genetic Predisposition to Disease
- Humans
- Indians, North American
- Matched-Pair Analysis
- Meiosis
- Middle Aged
- Prevalence