Multiple functional domains of human U2 small nuclear RNA: strengthening conserved stem I can block splicing.

doi:10.1128/mcb.12.12.5464-5473.1992

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Article

Multiple functional domains of human U2 small nuclear RNA: strengthening conserved stem I can block splicing.

Molecular and cellular biology - 1 Dec 1992

Wu J, Manley J L

Abstract excerpt

We showed previously that a branch site mutation in simian virus 40 early pre-mRNA that prevented small t antigen mRNA splicing could be efficiently suppressed by a compensatory mutation in a coexpressed U2 small nuclear (sn) RNA gene. We have now generated second-site mutations in this suppresso...

Topics

Base Sequence
Binding Sites
Humans
Molecular Sequence Data
Mutation
Nucleic Acid Conformation
RNA Splicing
RNA, Small Nuclear
Saccharomyces cerevisiae
Transfection

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