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Article

Multiple functional domains of human U2 small nuclear RNA: strengthening conserved stem I can block splicing.

Molecular and cellular biology - 1 Dec 1992

Wu J, Manley J L

Abstract excerpt

We showed previously that a branch site mutation in simian virus 40 early pre-mRNA that prevented small t antigen mRNA splicing could be efficiently suppressed by a compensatory mutation in a coexpressed U2 small nuclear (sn) RNA gene. We have now generated second-site mutations in this suppressor gene to investigate regions of U2 RNA required for function. A number of mutations in a putative stem at the 5' end...

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Identifiers

PMID: 1448079
DOI: 10.1128/mcb.12.12.5464-5473.1992
PMCID: PMC360484

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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