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Article

Inhibition and induction of cytochrome P4502E1-catalyzed oxidation by isoniazid in humans.

Clinical pharmacology and therapeutics - 1 Aug 1993

Zand R, Nelson S D, Slattery J T, Thummel K E, Kalhorn T F, Adams S P, Wright J M

Abstract excerpt

We studied the effect of isoniazid administration on the cytochrome P4502E1-catalyzed elimination of chlorzoxazone and acetaminophen. Isoniazid, 300 mg daily, was administered for 7 days to a group of 10 volunteer slow acetylators. Acetaminophen, 500 mg, and chlorzoxazone, 750 mg, were administered on separate occasions before isoniazid, during the period of isoniazid administration, and after the discontinuation...

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Source

Identifiers

PMID: 8354023
DOI: 10.1038/clpt.1993.125

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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