The effect of omeprazole pretreatment on acetaminophen metabolism in rapid and slow metabolizers of S-mephenytoin.

doi:10.1016/S0009-9236(97)90148-X

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Article

The effect of omeprazole pretreatment on acetaminophen metabolism in rapid and slow metabolizers of S-mephenytoin.

Clinical pharmacology and therapeutics - 1 Jul 1997

Sarich T, Kalhorn T, Magee S, al-Sayegh F, Adams S, Slattery J, Goldstein J, Nelson S, Wright J

Abstract excerpt

Omeprazole, a widely used and potent gastric proton pump inhibitor, induces cytochrome P450 (CYP) 1A2 in humans. Induction is most pronounced in slow metabolizers of S-mephenytoin because CYP2C19 (S-mephenytoin hydroxylase) is responsible for the elimination of omeprazole. Acetaminophen (INN, par...

Topics

Acetaminophen
Adult
Analgesics, Non-Narcotic
Anti-Ulcer Agents
Anticonvulsants
Female
Humans
Male
Mephenytoin
Middle Aged
Omeprazole
Phenotype
Reference Values

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