Article
Inhibition of the metabolism of paracetamol by isoniazid.
British journal of clinical pharmacology - 1 Feb 1991
Epstein M M, Nelson S D, Slattery J T, Kalhorn T F, Wall R A, Wright J M
Abstract excerpt
1. The effect of isoniazid given daily for 7 days on paracetamol (acetaminophen) kinetics and metabolism was studied in 10 healthy volunteers. Paracetamol, 500 mg, was given before isoniazid, on day 7 of isoniazid administration, and 2 days after the last dose of isoniazid. 2. On day 7, isoniazid...
Topics
- Acetaminophen
- Acetylation
- Adult
- Catechols
- Female
- Glutathione
- Humans
- Isoniazid
- Male
- Middle Aged
- Oxidation-Reduction
- Phenotype