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Article

Robustness of chlorzoxazone as an in vivo measure of cytochrome P450 2E1 activity.

British journal of clinical pharmacology - 1 Aug 2004

Ernstgård Lena, Warholm Margareta, Johanson Gunnar

Abstract excerpt

AIMS: Chlorzoxazone is metabolized by cytochrome P450 2E1 (CYP2E1) to a single oxidized metabolite, 6-hydroxychlorzoxazone. The aim of the study was to test the robustness of chlorzoxazone as an in vivo probe of CYP2E1 activity in humans, with emphasis on investigating short-term and long-term intra-individual variabilities and effects of different doses of the drug. In addition, the influences of body build,...

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Identifiers

PMID: 15255802
DOI: 10.1111/j.1365-2125.2004.02132.x
PMCID: PMC1884585

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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