Variability in the disposition of chlorzoxazone.

doi:10.1002/bdd.2510150706

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Article

Variability in the disposition of chlorzoxazone.

Biopharmaceutics & drug disposition - 1 Oct 1994

de Vries J D, Salphati L, Horie S, Becker C E, Hoener B A

Abstract excerpt

Chlorzoxazone is 6-hydroxylated by cytochrome P450 2E1 (CYP 2E1), which bioactivates many toxic and carcinogenic molecules. Seventeen volunteers of varying age, ethnicity, and gender received a 250 mg tablet of chlorzoxazone and their blood and urine were sampled frequently for 8 h. V/F = 42 +/- 21 L and CL/F = 412 +/- 120 mL min-1. Comparison of these values with a study by other investigators using a suspension...

Topics

Administration, Oral
Adult
Alcohol Drinking
Asian People
Black People
Blood Proteins
Chlorzoxazone
Chromatography, High Pressure Liquid
Cytochrome P-450 CYP2E1
Cytochrome P-450 Enzyme System
Female

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Humans

Hydroxylation

Male

Middle Aged

Oxidoreductases, N-Demethylating

Phenotype

Protein Binding

Source

Open in PubMed

Identifiers

PMID: 7849234
DOI: 10.1002/bdd.2510150706

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7849234-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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