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Article

Pharmacokinetics, N1-glucuronidation, and N4-acetylation of sulfa-6-monomethoxine in humans.

Drug metabolism and disposition: the biological fate of chemicals - 1 Jan 2000

Vree T B, Beneken Kolmer E W, Hekster Y A, Shimoda M, Ono M, Miura T

Abstract excerpt

Sulfamonomethoxine (S) is metabolized by O-dealkylation, N4-acetylation, and N1-glucuronidation. In humans, only N1-glucuronidation (12%) and N4-acetylation (36%) takes place. The N1-glucuronide is directly measured by HPLC. When N4-acetylsulfamonomethoxine (N4) is administered as the parent drug, N1-glucuronidation does not occur. After an oral dose, fast and slow acetylators show a similar t1/2 for S (25.0 +/-...

Topics

Acetylation
Adult
Biotransformation
Blood Proteins
Chromatography, High Pressure Liquid
Female
Glucuronates
Half-Life
Humans
Male
Middle Aged

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Phenotype

Protein Binding

Sulfamonomethoxine

Source

Identifiers

PMID: 1981528

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1981528-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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