Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Pharmacokinetics, N1-glucuronidation, and N4-acetylation of sulfa-6-monomethoxine in humans.

Drug metabolism and disposition: the biological fate of chemicals - 1 Jan 2000

Vree T B, Beneken Kolmer E W, Hekster Y A, Shimoda M, Ono M, Miura T

Abstract excerpt

Sulfamonomethoxine (S) is metabolized by O-dealkylation, N4-acetylation, and N1-glucuronidation. In humans, only N1-glucuronidation (12%) and N4-acetylation (36%) takes place. The N1-glucuronide is directly measured by HPLC. When N4-acetylsulfamonomethoxine (N4) is administered as the parent drug, N1-glucuronidation does not occur. After an oral dose, fast and slow acetylators show a similar t1/2 for S (25.0 +/-...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acetylation
Share to Biotransformation

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Blood Proteins

Share to Chromatography, High Pressure Liquid

Share to Glucuronates

Share to Half-Life

Share to Phenotype

Share to Protein Binding

Source

Identifiers

PMID: 1981528

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Pharmacokinetics, N1-glucuronidation, and N4-acetylation of sulfa-6-monomethoxine in humans.PMID 1981528Read ↗

Pharmacokinetics, N1-glucuronidation and N4-acetylation of sulfadimethoxine in man.Semantic proximity Read ↗

Pharmacokinetics and acetylation of sulfa-2-monomethoxine in humans.Semantic proximity Read ↗

Pharmacokinetics, metabolism and renal excretion of sulfatroxazole and its 5-hydroxy- and N4-acetyl-metabolites in man.Semantic proximity Read ↗

Pharmacokinetics, acetylation-deacetylation, renal clearance, and protein binding of sulphamerazine, N4-acetylsulphamerazine, and N4-trideuteroacetylsulphamerazine in 'fast' and 'slow' acetylators.Semantic proximity Read ↗

N-acetyltransferase (NAT) 1 and NAT2 enzyme activities drive interindividual variability in sulfamethoxazole N-acetylation.Semantic proximity Read ↗

N-acetylation and oxidative capacity in aged volunteers determined with sulfamethazine and antipyrine.Semantic proximity Read ↗

N-acetylation of the heterocyclic amine batracylin by human liver.Semantic proximity Read ↗

Formation and elimination of sulphamethoxazole hydroxylamine after oral administration of sulphamethoxazole.Semantic proximity Read ↗

Pharmacokinetics of N1-acetyl- and N4-acetylsulphamethoxazole in man.Semantic proximity Read ↗

Determination of the acetylator phenotype and pharmacokinetics of some sulphonamides in man.Semantic proximity Read ↗

Pharmacokinetic studies of sulfapyridine acetylation in the rabbit.Semantic proximity Read ↗

Mesalazine pharmacokinetics and NAT2 phenotype.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.