Modulation of CYP2E1 activity by isoniazid in rapid and slow N-acetylators.

doi:10.1111/j.1365-2125.1997.tb00039.x

Back to search

Article

Modulation of CYP2E1 activity by isoniazid in rapid and slow N-acetylators.

British journal of clinical pharmacology - 1 Jan 1997

O'Shea D, Kim R B, Wilkinson G R

Abstract excerpt

AIMS: An investigation was undertaken to compare the effects of isoniazid pretreatment on the CYP2E1-mediated 6-hydroxylation of chlorzoxazone in healthy subjects of known N-acetylator phenotype. METHODS: CYP2E1 activity was estimated based on the 6-hydroxylation of chlorzoxazone following single...

Topics

Acetylation
Administration, Oral
Adolescent
Adult
Analysis of Variance
Antitubercular Agents
Chlorzoxazone
Cytochrome P-450 CYP2E1
Enzyme Induction
Female
Humans
Hydroxylation
Isoniazid
Male
Muscle Relaxants, Central
Phenotype

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.