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Article

Modulation of CYP2E1 activity by isoniazid in rapid and slow N-acetylators.

British journal of clinical pharmacology - 1 Jan 1997

O'Shea D, Kim R B, Wilkinson G R

Abstract excerpt

AIMS: An investigation was undertaken to compare the effects of isoniazid pretreatment on the CYP2E1-mediated 6-hydroxylation of chlorzoxazone in healthy subjects of known N-acetylator phenotype. METHODS: CYP2E1 activity was estimated based on the 6-hydroxylation of chlorzoxazone following single dose (250 mg) oral administration to seven slow and eight rapid N-acetylators who were in good health. Separate...

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Source

Identifiers

PMID: 9056059
DOI: 10.1111/j.1365-2125.1997.tb00039.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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