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Article

Decreased acetylation of isoniazid in chronic renal failure

1 Dec 1993

Abstract excerpt

Pharmacokinetic parameters of isoniazid obtained from 37 normal subjects were compared with parameters obtained from 14 patients with chronic renal failure. In the 29 normal rapid acetylators and eight normal slow acetylators, the mean plasma half-life values of isoniazid were 1.54 +/- 0.31 and 3.68 +/- 0.59 hours, respectively. The plasma half-life values of isoniazid in patients with chronic renal failure...

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Identifiers

PMID: 8275616
DOI: 10.1038/clpt.1993.198

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