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Article

Variability of sequence surrounding the Xist gene in rodents suggests taxon-specific regulation of X chromosome inactivation.

PloS one - 1 Jan 2011

Shevchenko Alexander I, Malakhova Anastasia A, Elisaphenko Eugeny A, Mazurok Nina A, Nesterova Tatyana B, Brockdorff Neil, Zakian Suren M

Abstract excerpt

One of the two X chromosomes in female mammalian cells is subject to inactivation (XCI) initiated by the Xist gene. In this study, we examined in rodents (voles and rat) the conservation of the microsatellite region DXPas34, the Tsix gene (antisense counterpart of Xist), and enhancer Xite that have been shown to flank Xist and regulate XCI in mouse. We have found that mouse regions of the Tsix gene major promoter...

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Identifiers

PMID: 21826206
DOI: 10.1371/journal.pone.0022771
PMCID: PMC3149622

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