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Article

Functional studies of a germ-line polymorphism at codon 47 within the p53 gene.

American journal of human genetics - 1 Sept 1993

Felley-Bosco E, Weston A, Cawley H M, Bennett W P, Harris C C

Abstract excerpt

A rare germ-line polymorphism in codon 47 of the p53 gene replaces the wild-type proline (CCG) with a serine (TCG). Restriction analysis of 101 human samples revealed the frequency of the rare allele to be 0% (n = 69) in Caucasians and 4.7% (3/64, n = 32) among African-Americans. To investigate the consequence of this amino acid substitution, a cDNA construct (p53 mut47ser) containing the mutation was introduced...

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Source

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Identifiers

PMID: 8352280
PMCID: PMC1682404

Genes

CAT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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