Analysis of a germ line polymorphism of the p53 gene in lung cancer patients; discrete results with smoking history.

doi:10.1093/carcin/17.2.261

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Article

Analysis of a germ line polymorphism of the p53 gene in lung cancer patients; discrete results with smoking history.

Carcinogenesis - 1 Feb 1996

Murata M, Tagawa M, Kimura M, Kimura H, Watanabe S, Saisho H

Abstract excerpt

The p53 tumor suppressor gene is often mutated in various human cancers and a common polymorphism is known at codon 72 of exon 4, with two alleles encoding either arginine (CGC) or proline (CCC). Association of this polymorphism with any human cancer susceptibility has yet to be clarified. We hav...

Topics

Arginine
Base Sequence
Case-Control Studies
Disease Susceptibility
Female
Genes, p53
Genotype
Heterozygote
Homozygote
Humans
Lung Neoplasms
Male
Middle Aged
Molecular Sequence Data
Polymorphism, Genetic
Proline
Smoking

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