Article
An African-specific polymorphism in the TP53 gene impairs p53 tumor suppressor function in a mouse model.
Genes & development - 15 Apr 2016
Jennis Matthew, Kung Che-Pei, Basu Subhasree, Budina-Kolomets Anna, Leu Julia I-Ju, Khaku Sakina, Scott Jeremy P, Cai Kathy Q, Campbell Michelle R, Porter Devin K, Wang Xuting, Bell Douglas A, Li Xiaoxian, Garlick David S, Liu Qin, Hollstein Monica, George Donna L, Murphy Maureen E
Abstract excerpt
A nonsynonymous single-nucleotide polymorphism at codon 47 in TP53 exists in African-descent populations (P47S, rs1800371; referred to here as S47). Here we report that, in human cell lines and a mouse model, the S47 variant exhibits a modest decrease in apoptosis in response to most genotoxic stresses compared with wild-type p53 but exhibits a significant defect in cell death induced by cisplatin. We show that,...
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