Article
The African-specific S47 polymorphism of p53 alters chemosensitivity.
Cell cycle (Georgetown, Tex.) - 1 Oct 2016
Basu Subhasree, Barnoud Thibaut, Kung Che-Pei, Reiss Matthew, Murphy Maureen E
Abstract excerpt
The TP53 protein is known to affect the sensitivity of tumor cells to cell death by DNA damaging agents. We recently reported that human and mouse cells containing an African-specific coding region variant of p53, Pro47Ser (hereafter S47), are impaired in the transactivation of a small subset of p53 target genes including GLS2 and SCO2, and are markedly resistant to cisplatin. Further, mice containing this...
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