Article
The basic carboxy-terminal domain of human p53 is dispensable for both transcriptional regulation and inhibition of tumor cell growth.
Oncogene - 20 Jul 1995
Pellegata N S, Cajot J F, Stanbridge E J
Abstract excerpt
To investigate the relevance of the C-terminal domains of the human p53 tumor suppressor gene to its growth suppressive and transcriptional regulatory properties deletion mutants were generated which eliminated 30 (p53 delta 363), 60 (p53 delta 333) and 87 (p53 delta 306) amino acids from the C-t...
Topics
- Base Sequence
- Cell Division
- Cell Nucleus
- Cell Transformation, Neoplastic
- Gene Expression Regulation, Neoplastic
- Genes, p53
- Humans
- Lung Neoplasms
- Molecular Sequence Data
- Mutation
- Peptide Fragments
- Transcription, Genetic
- Transfection
- Tumor Cells, Cultured
- Tumor Suppressor Protein p53