Article
A link between increased transforming activity of lymphoma-derived MYC mutant alleles, their defective regulation by p107, and altered phosphorylation of the c-Myc transactivation domain.
Molecular and cellular biology - 1 Aug 1995
Hoang A T, Lutterbach B, Lewis B C, Yano T, Chou T Y, Barrett J F, Raffeld M, Hann S R, Dang C V
Abstract excerpt
The c-Myc protein is a transcription factor with an N-terminal transcriptional regulatory domain and C-terminal oligomerization and DNA-binding motifs. Previous studies have demonstrated that p107, a protein related to the retinoblastoma protein, binds to the c-Myc transcriptional activation domain and suppresses its activity. We sought to characterize the transforming activity and transcriptional properties of...
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