A link between increased transforming activity of lymphoma-derived MYC mutant alleles, their defective regulation by p107, and altered phosphorylation of the c-Myc transactivation domain.

doi:10.1128/MCB.15.8.4031

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Article

A link between increased transforming activity of lymphoma-derived MYC mutant alleles, their defective regulation by p107, and altered phosphorylation of the c-Myc transactivation domain.

Molecular and cellular biology - 1 Aug 1995

Hoang A T, Lutterbach B, Lewis B C, Yano T, Chou T Y, Barrett J F, Raffeld M, Hann S R, Dang C V

Abstract excerpt

The c-Myc protein is a transcription factor with an N-terminal transcriptional regulatory domain and C-terminal oligomerization and DNA-binding motifs. Previous studies have demonstrated that p107, a protein related to the retinoblastoma protein, binds to the c-Myc transcriptional activation doma...

Topics

Alleles
Amino Acid Sequence
Base Sequence
Burkitt Lymphoma
Cell Transformation, Neoplastic
Cyclins
DNA-Binding Proteins
Gene Expression Regulation, Neoplastic
Genes, myc
Humans
Models, Genetic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Molecular Sequence Data

Mutation

Nuclear Proteins

Phosphorylation

Protein Binding

Proto-Oncogene Proteins c-myc

Retinoblastoma-Like Protein p107

Source

Open in PubMed Open full text

Identifiers

PMID: 7623799
DOI: 10.1128/MCB.15.8.4031
PMCID: PMC230642

Genes

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7623799-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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