Article
Point mutation of the p53 gene resulting in splicing inhibition in small cell lung carcinoma.
Biochemical and biophysical research communications - 14 Dec 1990
Sameshima Y, Akiyama T, Mori N, Mizoguchi H, Toyoshima K, Sugimura T, Terada M, Yokota J
Abstract excerpt
The p53 gene is functionally inactivated mostly by point mutations resulting in amino acid substitutions in a wide variety of human cancers. We found a novel mutation of the p53 gene in a small cell lung carcinoma cell line, Lu-143. One of the allelic p53 genes was lost accompanied by loss of heterozygosity for chromosome 17. In the remaining allelic p53 gene, there was a single-base substitution of G to T at...
Topics
- Alleles
- Base Sequence
- Carcinoma, Small Cell
- Exons
- Gene Expression Regulation
- Genes, p53
- Humans
- Introns
- Lung Neoplasms
- Molecular Sequence Data
- Mutation