p53 functional loss in a colon cancer cell line with two missense mutations (218leu and 248trp) on separate alleles.

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

p53 functional loss in a colon cancer cell line with two missense mutations (218leu and 248trp) on separate alleles.

Cancer letters - 2 Jan 1996

Rand A, Glenn K S, Alvares C P, White M B, Thibodeau S M, Karnes W E

Abstract excerpt

We have sequenced p53 in three colon cancer cell lines capable of autonomous proliferation. SNU-C1 and SNU-C4 cells, whose autonomous growth is dependent upon autocrine stimulation of epidermal growth factor receptor (EGFR), had wildtype p53 sequence of exons 4-9. In contrast, an EGFR ligand-inde...

Topics

Alleles
Cell Division
Colonic Neoplasms
DNA Damage
DNA, Neoplasm
ErbB Receptors
Genes, p53
Heterozygote
Humans
Leucine
Mutation
Sequence Analysis, DNA
Tryptophan
Tumor Cells, Cultured
Tumor Suppressor Protein p53

Source

Open in PubMed

Identifiers

PMID: 8556707

Genes

EGFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8556707-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics