Statistical evaluation of multiple-locus linkage data in experimental species and its relevance to human studies: application to nonobese diabetic (NOD) mouse and human insulin-dependent diabetes mellitus (IDDM).

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Article

Statistical evaluation of multiple-locus linkage data in experimental species and its relevance to human studies: application to nonobese diabetic (NOD) mouse and human insulin-dependent diabetes mellitus (IDDM).

American journal of human genetics - 1 Sept 1993

Risch N, Ghosh S, Todd J A

Abstract excerpt

Common, familial human disorders generally do not follow Mendelian inheritance patterns, presumably because multiple loci are involved in disease susceptibility. One approach to mapping genes for such traits in humans is to first study an analogous form in an animal model, such as mouse, by using...

Topics

Animals
Chi-Square Distribution
Chromosome Mapping
Chromosomes, Human
Crosses, Genetic
Diabetes Mellitus, Type 1
Disease Models, Animal
Epistasis, Genetic
Female
Genetic Linkage
Genetic Predisposition to Disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Genotype

Humans

Likelihood Functions

Linear Models

Male

Mice

Mice, Inbred NOD

Source

Open in PubMed Open full text

Identifiers

PMID: 8352278
PMCID: PMC1682416

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8352278-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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