Article
Multidimensional genome scans identify the combinations of genetic loci linked to diabetes-related phenotypes in mice.
Human molecular genetics - 1 Jan 2006
Togawa Katsuhiko, Moritani Maki, Yaguchi Hiroshi, Itakura Mitsuo
Abstract excerpt
Most quantitative trait loci (QTL) studies have focused on detecting the genetic effects of individual QTLs. This study thoroughly dissected the genetic components of type 2 diabetic mice, including a search for epistatic interactions and multi-locus additive effects that result in variation in diabetes-related phenotypes. F2 population was generated from BKS.Cg-Leprdb+/+m and DBA/2 intercross and separated into...
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