The use of animal models in the study of complex disease: all else is never equal or why do so many human studies fail to replicate animal findings?

Abstract excerpt

The study of the genetics of complex human disease has met with limited success. Many findings with candidate genes fail to replicate despite seemingly overwhelming physiological data implicating the genes. In contrast, animal model studies of the same genes and disease models usually have more consistent results. We propose that one important reason for this is the ability to control genetic background in animal...

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