Mouse models of type 1 and type 2 diabetes derived from the same closed colony: genetic susceptibility shared between two types of diabetes.

doi:10.1093/ilar.45.3.268

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Article

Mouse models of type 1 and type 2 diabetes derived from the same closed colony: genetic susceptibility shared between two types of diabetes.

ILAR journal - 1 Jan 2004

Ikegami Hiroshi, Fujisawa Tomomi, Ogihara Toshio

Abstract excerpt

Except for rare subtypes of diabetes, both type 1 and type 2 diabetes are multifactorial diseases in which genetic factors consisting of multiple susceptibility genes and environmental factors contribute to the disease development. Due to complex interaction among multiple susceptibility genes and between genetic and environmental factors, genetic analysis of multifactorial diseases is difficult in humans. Inbred...

Topics

Animals
Animals, Laboratory
Diabetes Mellitus, Type 1
Diabetes Mellitus, Type 2
Disease Models, Animal
Genetic Predisposition to Disease
Mice
Mice, Inbred NOD

Source

Open in PubMed

Identifiers

PMID: 15229374
DOI: 10.1093/ilar.45.3.268

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