Article
Genomic clone for sandbar shark lambda light chain: generation of diversity in the absence of gene rearrangement.
Proceedings of the National Academy of Sciences of the United States of America - 1 Nov 1993
Hohman V S, Schuchman D B, Schluter S F, Marchalonis J J
Abstract excerpt
While the general structure of immunoglobulin chains has remained relatively unchanged throughout evolution, the organization of the genes encoding these molecules differs substantially. To understand how the rearranging immunoglobulin system arose, it is necessary to examine living representatives of the most early vertebrate phyla. Elasmo-branches, which include the sharks, skates, and rays, are the most...
Topics
- Amino Acid Sequence
- Animals
- Base Sequence
- Cloning, Molecular
- DNA Primers
- Gene Library
- Gene Rearrangement
- Genes, Immunoglobulin
- Genetic Variation
- Humans
- Immunoglobulin Joining Region