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Article

Distinct patterns of IgH structure and organization in a divergent lineage of chrondrichthyan fishes.

Immunogenetics - 1 Jan 1998

Rast J P, Amemiya C T, Litman R T, Strong S J, Litman G W

Abstract excerpt

Immunoglobulin heavy chain (IgH) genes in representative chondrichthyan fishes (sharks and skates) consist of independently functioning clusters, containing separate variable (VH), diversity (DH), and joining (JH) region elements and constant (CH) region exons. IgH loci have been characterized in Hydrolagus colliei (spotted ratfish), a modern representative of a major independent chondrichthyan lineage. Three...

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PMID: 9435342
DOI: 10.1007/s002510050353

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