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Article

The Complete Nucleotide Sequence of the Human Immunoglobulin Heavy Chain Variable Region Locus

7 Dec 1998

Abstract excerpt

The complete nucleotide sequence of the 957-kb DNA of the human immunoglobulin heavy chain variable (VH) region locus was determined and 43 novel VH segments were identified. The region contains 123 VH segments classifiable into seven different families, of which 79 are pseudogenes. Of the 44 VH segments with an open reading frame, 39 are expressed as heavy chain proteins and 1 as mRNA, while the remaining 4 are...

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Identifiers

PMID: 9841928
DOI: 10.1084/jem.188.11.2151

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