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Article

Extensive diversity of transcribed TCR-beta in phylogenetically primitive vertebrate.

Journal of immunology (Baltimore, Md. : 1950) - 1 Apr 1996

Hawke N A, Rast J P, Litman G W

Abstract excerpt

The genetic complexity of the expressed TCR Vbeta repertoire in Heterodontus francisci, the horned shark, a member of the most phylogenetically primitive vertebrate class in which TCR genes have been identified, is addressed. The sequences of 55 spleen cDNA clones encoding TCR-beta genes are compared, and 7 diverse Vbeta families are defined by overall sequence identity and clustering based on phylogenetic...

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PMID: 8786305

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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