Article
The variation in immunoglobulin heavy chain constant regions in evolution.
Seminars in immunology - 1 Dec 1994
Hsu E
Abstract excerpt
The sequences of immunoglobulin (Ig) heavy chain constant (C) region genes do not appear to be well conserved in evolution. The nature of C region change was examined by comparing VH and CH segment variability in the shark, which has numerous C mu as well as VH genes. The sequence diversity among VH was found to be similar to that among C mu 1, suggesting that one Ig segment does not change faster than the other....
Topics
- Amino Acid Sequence
- Animals
- Biological Evolution
- Genetic Variation
- Immunoglobulin Constant Regions
- Immunoglobulin Heavy Chains
- Molecular Sequence Data
- Sequence Homology, Amino Acid