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Article

Error-prone DNA repair activity during somatic hypermutation in shark B lymphocytes.

Journal of immunology (Baltimore, Md. : 1950) - 1 Nov 2010

Zhu Catherine, Hsu Ellen

Abstract excerpt

Sharks are representatives of the earliest vertebrates that possess an immune system utilizing V(D)J recombination to generate Ag receptors. Their Ab repertoire diversity is based in part on a somatic hypermutation process that introduces adjacent nucleotide substitutions of 2-5 bp. We have isolated mutant nonfunctional Ig rearrangements and intronic flank sequences to characterize the nonselected, intrinsic...

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Identifiers

PMID: 20921520
DOI: 10.4049/jimmunol.1000779
PMCID: PMC2959145

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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