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Article

Mutational activation of K-ras in nonneoplastic exocrine pancreatic lesions in relation to cigarette smoking status

15 Jan 1999

Abstract excerpt

BACKGROUND: Cigarette smoking is among the few unequivocal risk factors for the development of pancreatic ductal adenocarcinoma (PDAC). Activating mutations in codon 12 of the K-ras protooncogene is a frequent and early molecular event in the pathogenesis of PDAC and a variety of nonmalignant ductal pancreatic lesions. The molecular epidemiologic relation between heavy cigarette smoking and mutational activation...

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Identifiers

PMID: 10023699
DOI: 10.1002/(sici)1097-0142(19990115)85:2<326::aid-cncr9>3.0.co;2-o

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