Article
TFIIA induces conformational changes in TFIID via interactions with the basic repeat.
Molecular and cellular biology - 1 Nov 1992
Lee D K, DeJong J, Hashimoto S, Horikoshi M, Roeder R G
Abstract excerpt
DNA-binding studies with Saccharomyces cerevisiae TFIID point mutants indicated that TFIIA interacts with the basic repeat region of TFIID and induces structural changes. The latter was shown by the ability of TFIIA to compensate for TFIID point mutants defective for DNA binding. Interaction with...
Topics
- Base Sequence
- DNA
- Humans
- Molecular Sequence Data
- Mutation
- Promoter Regions, Genetic
- Protein Binding
- Protein Conformation
- Repetitive Sequences, Nucleic Acid
- TATA Box
- Temperature
- Transcription Factor TFIIA
- Transcription Factor TFIID
- Transcription Factors
- Transcription, Genetic