Article
Low frequency of NRAS and KRAS2 gene mutations in childhood myelodysplastic syndromes.
Cancer genetics and cytogenetics - 15 Oct 2004
Jekic Biljana, Novakovic Ivana, Lukovic Ljiljana, Kuzmanovic Milos, Popovic Branka, Pastar Irena, Milasin Jelena, Bunjevacki Gordana, Bunjevacki Vera
Abstract excerpt
In children, myelodysplastic syndromes (MDS) represent less then 10% of all hematological malignancies; consequently, molecular genetic studies dealing with this group of patients are scarce. We have analyzed 35 archival bone marrow samples of children with MDS for the presence of mutations in the first and second exons of the NRAS and KRAS2 genes. Mutations were detected with single-strand conformation...
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