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Article

Effect of RAS Pathway Gene Mutations on Survival in Myelodysplastic Syndrome: A Systematic Review and Meta-Analysis.

Cancer control : journal of the Moffitt Cancer Center - 1 Jan 2026

Eslalakawi Yasmin, Saad Mohamed Omar, Sanosi Amin S, Mesilhy Rowan, Al-Mashdali Abdulrahman F, Omar Nabil E, Saleh Ahmed O, Abdalla Elmustafa, Elfatih Amal, Mohamed Shehab F

Abstract excerpt

IntroductionMyelodysplastic syndromes (MDS) are clonal hematopoietic disorders characterized by ineffective hematopoiesis, cytopenia, and risk of progression to acute myeloid leukemia. Somatic mutations in RAS pathway, including NRAS, KRAS, and PTPN11, are known contributors to leukemogenesis, yet their prognostic significance in MDS remains incompletely defined. This systematic review and meta-analysis assesses...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Share to Protein Tyrosine Phosphatase, Non-Receptor Type 11

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Source

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Identifiers

PMID: 41804592
DOI: 10.1177/10732748261424957
PMCID: PMC12979904

Genes

KRAS
NRAS
PTPN11

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 23 Oct 2026.

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Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

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