Article
Genetic pathways in the pathogenesis of therapy-related myelodysplasia and acute myeloid leukemia.
Hematology. American Society of Hematology. Education Program - 1 Jan 2007
Pedersen-Bjergaard Jens, Andersen Morten T, Andersen Mette K
Abstract excerpt
In therapy-related myelodysplasia (t-MDS) and acute myeloid leukemia (t-AML), at least eight alternative genetic pathways have been defined based on characteristic recurrent chromosome abnormalities. Patients presenting as t-MDS and patients presenting as overt t-AML cluster differently in these pathways. The cytogenetic pattern depends on the type of leukemogenic therapy received: alkylating agents,...
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