Article
Persistence of an activating N-RAS oncogene mutation in clonogenic progenitor cells from an acute myeloid leukaemia patient in remission.
British journal of haematology - 1 Feb 1994
Zaheer H A, Bagnara M, Gibson F M, Robinson G, Rutherford T R, Gordon-Smith E C
Abstract excerpt
A patient with acute myeloid leukaemia (AML) with an activating N-RAS oncogene mutation was studied in a haemopoietic clonogenic progenitor cell assay. Individual colonies and clusters were analysed by polymerase chain reaction and oligonucleotide hybridization for the original mutation. The muta...
Topics
- Aged
- Base Sequence
- Bone Marrow
- DNA, Neoplasm
- Female
- Genes, ras
- Humans
- Leukemia, Myeloid, Acute
- Molecular Sequence Data
- Mutation
- Neoplastic Stem Cells
- Polymerase Chain Reaction
- Remission Induction