Multivariate genetic analysis of apo AI concentration and HDL subfractions: evidence for major locus pleiotropy.

doi:10.1002/gepi.1370100648

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Article

Multivariate genetic analysis of apo AI concentration and HDL subfractions: evidence for major locus pleiotropy.

Genetic epidemiology - 1 Jan 1993

Blangero J, Williams-Blangero S, Mahaney M C

Abstract excerpt

A major locus influencing apolipoprotein AI (apo AI) serum levels was detected using data from the Donner Laboratory Family Study. This locus accounts for 46% of the phenotypic variability in apo AI levels. Multivariate segregation analysis revealed that this major locus also has significant plei...

Topics

Apolipoprotein A-I
Computer Simulation
Female
Genetic Linkage
Genetic Predisposition to Disease
Humans
Likelihood Functions
Lipoproteins, HDL
Male
Models, Genetic
Models, Statistical
Multivariate Analysis
Phenotype

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