A multivariate method for detecting genetic linkage, with application to a pedigree with an adverse lipoprotein phenotype.

Article

A multivariate method for detecting genetic linkage, with application to a pedigree with an adverse lipoprotein phenotype.

American journal of human genetics - 1 Aug 1990

Amos C I, Elston R C, Bonney G E, Keats B J, Berenson G S

Abstract excerpt

The robust or model-free method for detecting linkage developed by Haseman and Elston for data from sib pairs is extended to incorporate observations of multiple traits on each individual. A method is proposed that estimates the linear function that results in the strongest correlation between th...

Topics

Apolipoproteins
Cholesterol, HDL
Cholesterol, LDL
Coronary Disease
Genetic Linkage
Genetic Markers
Humans
Lipoproteins
Models, Genetic
Multivariate Analysis
Pedigree
Phenotype
Risk Factors

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