Article
Genetic predictors of FCHL in four large pedigrees. Influence of ApoB level major locus predicted genotype and LDL subclass phenotype.
Arteriosclerosis and thrombosis : a journal of vascular biology - 1 Nov 1994
Jarvik G P, Brunzell J D, Austin M A, Krauss R M, Motulsky A G, Wijsman E
Abstract excerpt
The genetic basis of familial combined hyperlipidemia (FCHL) has eluded investigators for 20 years, despite the apparent segregation of FCHL as an autosomal dominant disorder affecting 1% to 2% of individuals. Etiologic heterogeneity and additive effects of traits controlled by other genetic loci...
Topics
- Adult
- Apolipoproteins B
- Chromosome Mapping
- Female
- Forecasting
- Genotype
- Humans
- Hyperlipidemia, Familial Combined
- Lipoproteins, LDL
- Male
- Pedigree
- Phenotype
- Regression Analysis