Article
Pleiotropy and genotype by diet interaction in a baboon model for atherosclerosis: a multivariate quantitative genetic analysis of HDL subfractions in two dietary environments.
Arteriosclerosis, thrombosis, and vascular biology - 1 Apr 1999
Mahaney M C, Blangero J, Rainwater D L, Mott G E, Comuzzie A G, MacCluer J W, VandeBerg J L
Abstract excerpt
We investigated dietary effects on pleiotropic relationships among 3 HDL cholesterol (C) subfractions (HDL1-C, HDL2-C, and HDL3-C; levels quantified by gradient gel electrophoresis) for 942 pedigreed baboons (Papio hamadryas) who were fed a basal (Chow) diet and a high cholesterol, saturated fat (HCSF) challenge diet. Using multivariate maximum likelihood methods we estimated heritabilities for all 6 traits,...
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